CAS Number: 92-87-5. A crystalline base prepared from
nitrobenzene and used especially in making dyes. Chemical
formula = C12H12N2. Molecular weight = 184.2 g/mol.
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Benzidine is no longer produced in the United States, although
benzidine-based dyes may be imported into this country. No
information is available on the acute (short-term) effects of
benzidine in humans by inhalation exposure but benzidine is
considered to be very acutely toxic to humans by ingestion.
Chronic (long-term) exposure to benzidine in humans may result
in injury to the bladder. Epidemiological studies have shown
occupational exposure to benzidine to result in an increased
risk of bladder cancer. Animal studies have reported various
tumor types at multiple sites from benzidine exposure via oral,
inhalation, and injection exposure. EPA has classified
benzidine as a Group A, known human carcinogen.