CAS Number: 106-99-0. A flammable, gaseous, open chain
hydrocarbon used in making synthetic rubbers. Chemical formula
= C4H6. Molecular weight = 54.092 g/mol.
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Motor vehicle exhaust is a constant source of 1,3-butadiene.
Although 1,3-butadiene breaks down quickly in the atmosphere, it
is usually found in ambient air at low levels in urban and
suburban areas. Acute (short-term) exposure to 1,3-butadiene by
inhalation in humans results in irritation of the eyes, nasal
passages, throat, and lungs. Epidemiological studies have
reported a possible association between 1,3-butadiene exposure
and cardiovascular diseases. Epidemiological studies of workers
in rubber plants have shown an association between 1,3-butadiene
exposure and increased incidence of leukemia. Animal studies
have reported tumors at various sites from 1,3-butadiene
exposure. EPA has classified 1,3-butadiene as a Group B2,
probable human carcinogen.