CAS Number: 822-06-0. A colorless liquid with an irritating
odor. It is used as a chemical intermediate in the production of
light-stable, weather-resistant urethane coatings and elastomers.
Chemical Formula - C8H12N2O2. Molecular weight =
168.22 g/mol.
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Hexamethylene diisocyanate is used as a polymerizing agent in
polyurethane paints and coatings. Acute (short-term) exposure to
high concentrations of hexamethylene diisocyanate in humans can
cause pulmonary edema, coughing, and shortness of breath.
Hexamethylene diisocyanate is also extremely irritating to the
eyes, nose, and throat. Human studies have suggested that
chronic (long-term) exposure to hexamethylene diisocyanate may
cause chronic lung problems. Animal studies have reported
respiratory effects from chronic inhalation exposure and skin
irritation and sensitization from dermal exposure to
hexamethylene diisocyanate. No information is available on the
reproductive, developmental, or carcinogenic effects of
hexamethylene diisocyanate in humans. EPA has not classified
hexamethylene diisocyanate for carcinogenicity.