p-Cresol

Ambient air contains low levels of cresols from automobile
exhaust, power plants, and oil refineries. Acute (short-term)
inhalation exposure by humans to mixed cresols results in
respiratory tract irritation, with symptoms such as dryness,
nasal constriction, and throat irritation. Mixed cresols are
also strong dermal irritants. No information is available on the
chronic (long-term) effects of mixed cresols in humans, while
animal studies have reported effects on the blood, liver, kidney,
and central nervous system (CNS), and reduced body weight, from
oral and inhalation exposure to mixed cresols. Several animal
studies suggest that o-cresol, m-cresol, and p-cresol may act as
tumor promotors. EPA has classified o-cresol, m-cresol, and
p-cresol as Group C, possible human carcinogens.