CAS Number: 542-75-6. A colorless liquid with a sweet,
chloroform-like odor. Used in the production of soil fumigants
for parasitic nematodes. Chemical formula = C3H4Cl2. Molecular
weight = 110.98 g/mol.
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1,3-Dichloropropene is used as a component in formulations for
soil fumigants. Acute (short-term) inhalation exposure of humans
following a spill caused mucous membrane irritation, chest pain,
and breathing difficulties. Effects on the lung have been
observed in rats acutely exposed to 1,3-dichloropropene by
inhalation. Chronic (long-term) dermal exposure may result in
skin sensitization in humans. Damage to the nasal mucosa and
urinary bladder are the primary health effects of rodents
chronically exposed to 1,3-dichloropropene by inhalation.
Information on the carcinogenic effects of 1,3-dichloropropene in
humans is limited; two cases of histiocytic lymphomas and one
case of leukemia have been reported in humans accidentally
exposed by inhalation to concentrated vapors during cleanup of a
tank truck spill. An increased incidence of bronchioalveolar
adenomas has been reported in male mice exposed by inhalation but
not in rats or female mice. EPA has classified
1,3-dichloropropene as a Group B2, probable human carcinogen.